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Sandor Medicaids

Cardiovascular - CUSTODIOL-HTK SOLUTION Cardioplegia

The Only Single Shot Cardioplegia

Custodiol HTK (Histidine - Tryptophan - Ketoglutarate) Solution is used by Leading Cardiac Surgery Centers as a cardioplegic solution worldwide. A product approved by US FDA as a Medical Device and being a Multi - Organ solution is also the solution of choice as an organ preservation solution for Heart Transplantation.

SAFETY FEATURES

  • LOW POTASSIUM
  • LOW VISCOSITY

CLINICAL BENEFITS

  • Only solution used as Single Shot Cardioplegia for prolonged ishchemia
  • No Surface Cooling
  • No Retrocardiac Cooling
  • No Obligatory Reperfusion
  • High rate of spontaneous return to sinus rhythm
  • Minimized cell necrosis
  • Less depletion of ATP stores
  • Remarkably increased protective potency
  • Better Intra & Post Operative Scenarios

CUSTODIOL IS MAINLY USED IN THE CASES OF

  • Aortic Stenois
  • Mitral Valve Defects
  • In Born Heart Defects with no Aortic Insufficiency
  • Ascending Aneurysms
  • Hypertrophic Obstructive Cardiomyopathy

    In-situ protection : Due to high systemic tolerance all kinds of operation procedures ishchemic organs are possible such
    as a heart surgery

PROPERTIES OF CUSTODIOL

ADVANTAGES OF CUSTODIOL
Low potassium concentration to minimize risks In-situ an during hypothermic storage
Low sodium concentration of safe organ inactivation Rapid homogenous cooling due to low viscosity
Extended buffer capacity only possible with high histidine/histidine-HCL concentration Superior recovery of function
Tryptophane supports membrane integrity Excellent ischemic tolerance
Alpha-ketoglutarate serves as a substrate for aerobic energy production during the induction of cardioplegia,and when restarting the heart High buffering capacity Easier surgical handling due to excellent visibility
Reduced risk of postaggression syndrome
HTK is perfused as a cold solution, so that its hypothermic effect contributes to a decreased metabolic rate Virtual absence of side effects Shortened postoperative intensive care period
All components of HTK-Solution are naturally occurring physiological substances except for the inert mannitol, therefore no toxic effects have ever been observed Simple perfusion technique (ready-to-use, no additives or preparation ) saves the cost of filters, additives and staff time

Composition: 1000ml of the solution contains
0.8766g Sodium Chloride 15.0 mmol
0.6710g Potassium Chloride 9.0 mmol
0.8132g Magnesium Chloride  
6.000 H2O 4.0 mmol
3.7733g Histidine Hydrochloride Monohydrate 18.0 mmol
27.9289 Histidine 180.0 mmol
0.4045g Tryptophan 2.0 mmol
5.4651g Mannitol 30.0 mmol
0.0022g Calcium Chloride  
2.000 H2O 0.015 mmol
0.1842g Potassium Hydrogen 2 Ketoglutarate 1.0 mmol


Presentation of CUSTODIOL
BOTTLES OF: 100 ml 500 ml 1000 ml
PLASTIC BAGS OF: 1000 ml 2000 ml 5000 ml

CUSTODIOL is utilized in more than 50,000 surgical procedures

 
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